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Issue 30, 2017
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A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C–H insertion

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Abstract

Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals VIA bidirectional C–H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).

Graphical abstract: A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C–H insertion

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Publication details

The article was received on 18 Jan 2017, accepted on 24 Mar 2017 and first published on 24 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00459A
Citation: Chem. Commun., 2017,53, 4219-4221
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    A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C–H insertion

    R. J. Lepage, J. M. White and M. J. Coster, Chem. Commun., 2017, 53, 4219
    DOI: 10.1039/C7CC00459A

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