Issue 20, 2017
From the journal:

Chemical Communications

Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging†

David A. Anders,ab   Salvatore Bongarzone,b   Robin Fortt,b   Antony D. Gee*b  and  Nicholas J. Long ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Imperial College London, London SW7 2AZ, UK
E-mail: n.long@imperial.ac.uk

b Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London SE1 7EH, UK

Abstract

The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.

Graphical abstract: Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging

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Article information

DOI
https://doi.org/10.1039/C7CC00319F
Article type
Communication
Submitted
13 Jan 2017
Accepted
21 Feb 2017
First published
24 Feb 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 2982-2985

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Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging

D. A. Anders, S. Bongarzone, R. Fortt, A. D. Gee and N. J. Long, Chem. Commun., 2017, 53, 2982 DOI: 10.1039/C7CC00319F

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