Issue 25, 2017

Characterization of DNA duplex unzipping through a sub-2 nm solid-state nanopore

Abstract

Herein, the unzipping and translocation of DNA duplexes through a sub-2 nm silicon nitride (SiNx) solid-state nanopore have been demonstrated by well-resolved three-level blockades. In order to examine our observations, we applied a simple model which is applicable to the unzipping and translocation processes of DNA duplexes through solid-state nanopores. The generation of these highly recognizable signatures is an important step towards the real applications of solid-state nanopores in complex samples.

Graphical abstract: Characterization of DNA duplex unzipping through a sub-2 nm solid-state nanopore

Supplementary files

Article information

Article type
Communication
Submitted
04 Jan 2017
Accepted
28 Feb 2017
First published
28 Feb 2017

Chem. Commun., 2017,53, 3539-3542

Characterization of DNA duplex unzipping through a sub-2 nm solid-state nanopore

Y. Lin, X. Shi, S. Liu, Y. Ying, Q. Li, R. Gao, F. Fathi, Y. Long and H. Tian, Chem. Commun., 2017, 53, 3539 DOI: 10.1039/C7CC00060J

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