JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.
The article was received on 12 Dec 2016, accepted on 23 Jan 2017 and first published on 23 Jan 2017
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