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Issue 14, 2017
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Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

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Abstract

A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp3–H bonds took place twice at the same position in the whole reaction process. Preliminary mechanistic studies by in situ IR revealed that the second C–H palladation and reductive elimination might be slow steps.

Graphical abstract: Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

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Publication details

The article was received on 22 Nov 2016, accepted on 23 Jan 2017 and first published on 23 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09332A
Citation: Chem. Commun., 2017,53, 2294-2297
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    Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

    K. Wu, L. Meng, M. Huai, Z. Huang, C. Liu, X. Qi and A. Lei, Chem. Commun., 2017, 53, 2294
    DOI: 10.1039/C6CC09332A

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