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Issue 6, 2017
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Catalyst-free N-methylation of amines using CO2

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Abstract

Recently, utilizing CO2 as a methylation reagent to construct functional chemicals has attracted significant attention. However, the conversion of CO2 is still a challenge due to its inherent inertness. In this study, we have developed a catalyst-free N-methylation of amines to prepare numerous methylamines using CO2 as a methyl source. By utilizing 2 eq. PhSiH3 as the reductant, amines could undergo N-methylation under 1 atm of CO2 in DMF at 90 °C. Aliphatic and aromatic amines were compatible, generating the desired products in up to 95% yield.

Graphical abstract: Catalyst-free N-methylation of amines using CO2

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Publication details

The article was received on 14 Nov 2016, accepted on 17 Dec 2016 and first published on 19 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC09072A
Citation: Chem. Commun., 2017,53, 1148-1151
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    Catalyst-free N-methylation of amines using CO2

    H. Niu, L. Lu, R. Shi, C. Chiang and A. Lei, Chem. Commun., 2017, 53, 1148
    DOI: 10.1039/C6CC09072A

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