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Issue 11, 2017
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Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

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Abstract

It is important to achieve diverse functionalization of tertiary anilines due to their importance in biological molecules, pharmaceutical, functional materials, and ligands. A straightforward Pd/Cu-catalyzed oxidative C–H bond activation/N-dealkylative carbonylation of tertiary [1,1′-biphenyl]-2-anilines towards the synthesis of various biologically important phenanthridin-6(5H)-ones has been developed. A wide range of functional groups are well tolerated in this transformation. Moreover, O2 is utilized as the terminal oxidant to promote the oxidative carbonylation process.

Graphical abstract: Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

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Publication details

The article was received on 29 Oct 2016, accepted on 09 Jan 2017 and first published on 12 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08701A
Citation: Chem. Commun., 2017,53, 1908-1911
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    Pd/Cu-Catalyzed aerobic oxidative aromatic C–H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

    R. Shi, H. Niu, L. Lu and A. Lei, Chem. Commun., 2017, 53, 1908
    DOI: 10.1039/C6CC08701A

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