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Issue 2, 2017
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Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

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Abstract

Fluorophores are indispensable for imaging biological processes. We report the design and synthesis of azide-tagged boronic acid salicylidenehydrazone (BASHY) dyes and their use for site-selective labelling of Annexin V. The Annexin V-BASHY conjugate maintained function and fluorescence as demonstrated by the targeted detection of apoptotic cells.

Graphical abstract: Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

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Publication details

The article was received on 28 Oct 2016, accepted on 25 Nov 2016 and first published on 30 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC08671C
Citation: Chem. Commun., 2017,53, 368-371
  • Open access: Creative Commons BY license
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    Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells

    P. M. S. D. Cal, F. Sieglitz, F. M. F. Santos, C. Parente Carvalho, A. Guerreiro, J. B. Bertoldo, U. Pischel, P. M. P. Gois and G. J. L. Bernardes, Chem. Commun., 2017, 53, 368
    DOI: 10.1039/C6CC08671C

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