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Issue 8, 2017
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Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

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Abstract

We report the synthesis of a 5-formyl-2′-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.

Graphical abstract: Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

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Publication details

The article was received on 28 Oct 2016, accepted on 28 Dec 2016 and first published on 04 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08670E
Citation: Chem. Commun., 2017,53, 1389-1392
  • Open access: Creative Commons BY license
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    Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides

    F. Kawasaki, P. Murat, Z. Li, T. Santner and S. Balasubramanian, Chem. Commun., 2017, 53, 1389
    DOI: 10.1039/C6CC08670E

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