Issue 4, 2017

A new way to do an old reaction: highly efficient reduction of organic azides by sodium iodide in the presence of acidic ion exchange resin

Abstract

Organic azides are readily reduced to the corresponding amines by treatment with sodium iodide in the presence of acidic ion exchange resin. The process, optimal when performed at 40 °C and 200 mbar pressure on a rotatory evaporator, is extremely efficient, clean, and tolerant of a variety of functional groups.

Graphical abstract: A new way to do an old reaction: highly efficient reduction of organic azides by sodium iodide in the presence of acidic ion exchange resin

Supplementary files

Article information

Article type
Communication
Submitted
25 Oct 2016
Accepted
14 Dec 2016
First published
14 Dec 2016

Chem. Commun., 2017,53, 713-715

A new way to do an old reaction: highly efficient reduction of organic azides by sodium iodide in the presence of acidic ion exchange resin

K. Suthagar and A. J. Fairbanks, Chem. Commun., 2017, 53, 713 DOI: 10.1039/C6CC08574A

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