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Issue 1, 2017
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Au(III) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

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Abstract

The HIV nucleocapsid NCp7–SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for “non-covalent” molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent “fixation” by Au–Cys bond formation providing a chemotype for a new distinct class of nucleocapsid–nucleic acid antagonist.

Graphical abstract: Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

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Publication details

The article was received on 02 Oct 2016, accepted on 09 Nov 2016 and first published on 09 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC07970A
Citation: Chem. Commun., 2017,53, 91-94
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    Au(III) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists

    S. R. Spell, J. B. Mangrum, E. J. Peterson, D. Fabris, R. Ptak and N. P. Farrell, Chem. Commun., 2017, 53, 91
    DOI: 10.1039/C6CC07970A

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