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Issue 2, 2017
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[18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

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Abstract

[18F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [18F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes2)]+, then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [18F]-setoperone.

Graphical abstract: [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

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Publication details

The article was received on 21 Jun 2016, accepted on 30 Nov 2016 and first published on 30 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC05168E
Citation: Chem. Commun., 2017,53, 340-343
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    [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

    C. Perrio, S. Schmitt, D. Pla, F. P. Gabbaï, K. Chansaenpak, B. Mestre-Voegtle and E. Gras, Chem. Commun., 2017, 53, 340
    DOI: 10.1039/C6CC05168E

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