[18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

Abstract

[¹⁸F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [¹⁸F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph₂MeP)C₆H₄(BMes₂)]⁺, then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [¹⁸F]-setoperone.