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Issue 2, 2017
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Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

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Abstract

Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, we employ a novel biodegradable azide containing polymer in the formulation of polymeric nanoparticles and show that these particles can then be functionalized, with biorthogonal click reactions, to alter their surface appearance and their ability to interact with biological systems.

Graphical abstract: Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

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Publication details

The article was received on 10 Oct 2016, accepted on 24 Nov 2016 and first published on 16 Dec 2016


Article type: Communication
DOI: 10.1039/C6BM00721J
Citation: Biomater. Sci., 2017,5, 211-215
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    Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

    J. Olejniczak, G. Collet, V. A. Nguyen Huu, M. Chan, S. Lee and A. Almutairi, Biomater. Sci., 2017, 5, 211
    DOI: 10.1039/C6BM00721J

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