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Versatility of Carbon Paste Electrode Coupled to Differential Pulse Voltammetry for Determination of Lisinopril with its Associations (Hydrochlorothiazide and Amlodipine)

Abstract

Lisinopril (LNP) is angiotensin converting enzyme inhibitor found formulated with a diuretic, hydrochlorothiazide (HCTZ), or with a calcium channel blocker, amlodipine (AML), in a single tablet for treatment of hypertension. In this work, for the first time, two analytical methods are proposed for the determination of pairs of antihypertensives (HCTZ and LNP or AML and LNP). Both methods are based in the use of a carbon paste electrode (CPE) coupled with differential pulse voltammetry (DPV). In the cyclic voltammetry measurements, three very well-resolved and reproducible oxidative processes of AML, HCTZ and LNP were found at 0.65 V, 0.76 V and 0.99 V (vs Ag/AgCl (3.0 mol L–1 KCl)), respectively, which were related to irreversible redox processes and the current is mostly controlled by diffusion of the three drugs to the CPE surface. pH, supporting electrolyte and instrumental parameters of DPV were optimized. Analytical parameters such as linearity ranges, correlation coefficients and detection limits were evaluated. The viability of the proposed methods was successfully assessed by simultaneous quantification of the studied drugs in commercially available pharmaceutical formulations and also in spiked tap water sample. These methods represent an effective, inexpensive, no extraction or preconcentration procedures, easily accessible and alternative tool for the determination of LNP with its associations (HCTZ or AML) for analytical routine analysis or as protocol for analysis of environmental samples.

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Publication details

The article was received on 11 Jun 2017, accepted on 12 Jul 2017 and first published on 12 Jul 2017


Article type: Paper
DOI: 10.1039/C7AY01455D
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Versatility of Carbon Paste Electrode Coupled to Differential Pulse Voltammetry for Determination of Lisinopril with its Associations (Hydrochlorothiazide and Amlodipine)

    C. F. Valezi, A. P. P. Eisele and E. R. Sartori, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01455D

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