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Proton-Propelled Methyl-tert-butyl Ether Extraction for High Efficient Mass Spectrometric Analysis of Phospholipid

Abstract

ABSTRACT Proton-driven molecular partitioning on aqueous/organic interfaces has significantly improved collection efficiency of bipolar phospholipids during the two-phase liquid/liquid extraction and rendered the supra-sensitivity in the tandem mass spectrometric analysis. The underlying mechanism is proposed by combined factors of ion-pair and charge transfer, in which phospholipids would selectively penetrate organic/aqueous interface upon their distinct pKa value and intrinsic hydrophobicity.

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Publication details

The article was received on 17 May 2017, accepted on 15 Jul 2017 and first published on 17 Jul 2017


Article type: Communication
DOI: 10.1039/C7AY01250K
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Proton-Propelled Methyl-tert-butyl Ether Extraction for High Efficient Mass Spectrometric Analysis of Phospholipid

    B. Nie, Q. Zhou and X. Ye, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01250K

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