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Issue 31, 2017
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Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

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Abstract

Proton-driven molecular partitioning on aqueous/organic interfaces has significantly improved the collection efficiency of bipolar phospholipids during two-phase liquid/liquid extraction, and it has enabled supra-sensitivity in tandem mass spectrometric analysis. The underlying mechanism has been proposed by the combined factors of ion-pair and charge transfer, in which phospholipids selectively penetrate the organic/aqueous interface due to their distinct pKa value and intrinsic hydrophobicity.

Graphical abstract: Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

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Publication details

The article was received on 17 May 2017, accepted on 15 Jul 2017 and first published on 17 Jul 2017


Article type: Communication
DOI: 10.1039/C7AY01250K
Citation: Anal. Methods, 2017,9, 4491-4495
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    Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

    Q. Zhou, X. Ye and B. Nie, Anal. Methods, 2017, 9, 4491
    DOI: 10.1039/C7AY01250K

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