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Amino-terminated hyper branched polyamidoamine polymers grafted magnetic graphene oxide nano sheets as efficient sorbent for extraction of selective serotonin reuptake inhibitors from plasma sample

Abstract

In this study, covalently bonded third generation dendrimer to magnetic graphene oxide nanosheets (DMGO) were prepared. Taking advantages of large surface area, excellent biocompatibility and abundant functional groups, DMGO was used as an ideal sorbent for preconcentration and determination of four important selective serotonin reuptake inhibitors (citalopram, sertraline, fluvoxamine and fluoxetine). The successful synthesis of DMGO was confirmed by Fourier-transform infrared spectra (FT-IR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The factors that affect the extraction process such as pH, amount of sorbent and extraction time were optimized by central composite design (CCD) and desirability function (DF). The intra-day precisions (RSD %) were lower than 4.91 % and the method displays a wide linear range. The limit of detection for citalopram, sertraline, fluvoxamine and fluoxetine in aqueous samples are 0.3, 0.3, 0.6, and 0.9 ng mL-1, respectively. It was applied to determine selective serotonin reuptake inhibitors (SSRIs) in plasma sample and gave recoveries higher than 89 %. Finally, the sorbent was reused for 20 times without a significant decrease in extraction recovery.

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Publication details

The article was received on 06 May 2017, accepted on 09 Jul 2017 and first published on 10 Jul 2017


Article type: Paper
DOI: 10.1039/C7AY01166K
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Amino-terminated hyper branched polyamidoamine polymers grafted magnetic graphene oxide nano sheets as efficient sorbent for extraction of selective serotonin reuptake inhibitors from plasma sample

    Z. Lotfi, H. Mousavi and S. M. Sajjadi, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01166K

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