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Quantitative analysis of salvianolic acids, ginsenosides and borneols using 1H qNMR for quality control of Compound Danshen Dripping Pill

Abstract

Compound Danshen Dripping Pill (CDDP) is a Chinese herbal medicinal preparation composed of Salviae miltiorrhizae Radix and two other Chinese medicines, Notoginseng Radix and Borneolum. The main components of CDDP are protocatechuic aldehyde, danshensu, salvianolic acid A, rosmarinic acid, ginsenoside Rg1, ginsenoside Rb1, l-(–)-borneol and isoborneol. The complex composition of CDDP, which contains phenolic acids, ginseng saponins and borneols, makes quantitative analysis difficult using traditional methods. Therefore, a fast and accurate 1H qNMR method was established that can simultaneously determine the eight main components of CDDP. The qNMR method was well validated and successfully applied in the determination of ten sample batches. The vector cosine angle method was used for further analysis of the results to evaluate sample quality. The results indicate that the qNMR method is suitable for quality control of CDDP and has potential as an easy alternative for analysis of other complex Traditional Chinese Medicines (TCMs) that require two or more traditional instruments for comprehensive quantitative analysis.

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Publication details

The article was received on 10 Apr 2017, accepted on 16 Aug 2017 and first published on 17 Aug 2017


Article type: Communication
DOI: 10.1039/C7AY00938K
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Quantitative analysis of salvianolic acids, ginsenosides and borneols using 1H qNMR for quality control of Compound Danshen Dripping Pill

    X. Chen, J. Qi and B. Yu, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY00938K

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