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Issue 41, 2016
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Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

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Abstract

A global upsurge in antibiotic resistance has led to research in metal-based antimicrobial therapy. Nonetheless, the clinical translation of metal oxides is often hampered by their poor aqueous solubility. This work unravels the surfactant-free synthesis of a water-soluble PEGylated nanographene oxide/zinc-doped copper oxide complex (NGO-PEG–Zn–CuO) with superior antibacterial activity. We uncover its mechanism of bacterial cell death over E. coli and S. aureus associated with oxidative stress and high production of reactive oxygen species (ROS) compared to NGO–ZnCuO, ZnCuO and NGO-PEG. A simple, one-step sonochemical technique is employed to deposit the Zn–CuO nanoparticles (NPs) on NGO-PEG. This complex demonstrates excellent aqueous solubility in different physiological solutions, including serum. Moreover, it exhibits excellent stability in water for a period of more than two months with almost no cytotoxicity effect on HeLa cells. Taken together, these results display the superior potency of the NGO-PEG–ZnCuO complex as a soluble and non-toxic compound with enhanced antibacterial properties.

Graphical abstract: Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

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Publication details

The article was received on 11 Jul 2016, accepted on 14 Sep 2016 and first published on 15 Sep 2016


Article type: Paper
DOI: 10.1039/C6TB01728B
Citation: J. Mater. Chem. B, 2016,4, 6706-6715
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    Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

    R. K. Mishra, Y. Shalom, V. B. Kumar, J. H. T. Luong, A. Gedanken and E. Banin, J. Mater. Chem. B, 2016, 4, 6706
    DOI: 10.1039/C6TB01728B

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