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Issue 25, 2016
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Silica@zirconia@poly(malic acid) nanoparticles: promising nanocarriers for theranostic applications

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Abstract

Silica@zirconia@poly(malic acid) nanocarriers of 110 nm mean diameter were designed, synthesized and characterized for the targeted delivery of diagnostic and therapeutic 99mTc to folate-overexpressing tumors. An important achievement was that a multifunctional L-(−)-malic-acid-based copolymer was formed in situ at the surface of the inorganic cores in a single synthetic step incorporating L-(−)-malic acid, β-cyclodextrin rings, folic acid moieties, and polyethylene glycol chains. Morphological and in-depth structural analysis of the particles proved their core@shell structure. Stability experiments in aqueous media evidenced that stable suspensions can be obtained from the lyophilized powder in 10 mM phosphate buffer at pH 7.4. During 14-day degradation experiments, the nanoparticles were found to be slowly dissolving (including inorganic core) in saline and also in total cell medium. An in vitro toxicity assay on hepatocytes showed a concentration-dependent decrease of cell viability down to 63 ± 1% at the highest applied concentration (0.5 mg ml−1). Proof of concept experiments of technetium-99m radiolabelling and in vivo labelling stability are presented.

Graphical abstract: Silica@zirconia@poly(malic acid) nanoparticles: promising nanocarriers for theranostic applications

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Publication details

The article was received on 03 May 2016, accepted on 25 May 2016 and first published on 25 May 2016


Article type: Paper
DOI: 10.1039/C6TB01102K
Citation: J. Mater. Chem. B, 2016,4, 4420-4429
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    Silica@zirconia@poly(malic acid) nanoparticles: promising nanocarriers for theranostic applications

    L. Naszályi Nagy, A. Polyak, J. Mihály, Á. Szécsényi, I. Cs. Szigyártó, Zs. Czégény, E. Jakab, P. Németh, B. Magda, P. Szabó, Zs. Veres, K. Jemnitz, I. Bertóti, R. P. Jóba, Gy. Trencsényi, L. Balogh and A. Bóta, J. Mater. Chem. B, 2016, 4, 4420
    DOI: 10.1039/C6TB01102K

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