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Issue 29, 2016
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Tuning stiffness of cell-laden hydrogel via host–guest interactions

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Abstract

We report a dynamic hydrogel system with on-demand tunable matrix stiffness. The hydrogels are formed by thiol–allylether photo-click reaction using thiolated poly(vinyl alcohol) (TPVA), 4-arm poly(ethylene glycol)-allylether (PEG4AE), and mono-functional β-cyclodextrin-allylether (βCDAE). Adamantane-functionalized 4-arm PEG (PEG4AD) is used to stiffen hydrogels, whereas unmodified βCD is used to induce gel softening. The stiffening and softening processes are fully reversible and these hydrogels are ideal for investigating the effect of matrix mechanics on cell fate processes.

Graphical abstract: Tuning stiffness of cell-laden hydrogel via host–guest interactions

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Publication details

The article was received on 11 Apr 2016, accepted on 17 Jun 2016 and first published on 20 Jun 2016


Article type: Communication
DOI: 10.1039/C6TB00890A
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2016,4, 4969-4974
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    Tuning stiffness of cell-laden hydrogel via host–guest interactions

    H. Shih and C. Lin, J. Mater. Chem. B, 2016, 4, 4969
    DOI: 10.1039/C6TB00890A

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