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Issue 7, 2016
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Ruthenium(II) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

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Abstract

Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(II) complex-photosensitizer, the polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed and showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) and imaging of cancer. Exposure to NIR light leads to two-photon excitation of the Ru(II)-complex which allows efficient simultaneous cancer-imaging and targeted PDT therapy with the functionalized biodegradable pSiNP nanocarriers.

Graphical abstract: Ruthenium(ii) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

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Publication details

The article was received on 23 Dec 2015, accepted on 14 Jan 2016 and first published on 14 Jan 2016


Article type: Paper
DOI: 10.1039/C5TB02726H
Citation: J. Mater. Chem. B, 2016,4, 1337-1342
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    Ruthenium(II) complex-photosensitized multifunctionalized porous silicon nanoparticles for two-photon near-infrared light responsive imaging and photodynamic cancer therapy

    N. Ž. Knežević, V. Stojanovic, A. Chaix, E. Bouffard, K. E. Cheikh, A. Morère, M. Maynadier, G. Lemercier, M. Garcia, M. Gary-Bobo, J. Durand and F. Cunin, J. Mater. Chem. B, 2016, 4, 1337
    DOI: 10.1039/C5TB02726H

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