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Issue 29, 2016
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DNA brick self-assembly with an off-lattice potential

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Abstract

We report Monte Carlo simulations of a simple off-lattice patchy-particle model for DNA ‘bricks’. We relate the parameters that characterise this model with the binding free energy of pairs of single-stranded DNA molecules. We verify that an off-lattice potential parameterised in this way reproduces much of the behaviour seen with a simpler lattice model we introduced previously, although the relaxation of the geometric constraints leads to a more error-prone self-assembly pathway. We investigate the self-assembly process as a function of the strength of the non-specific interactions. We show that our off-lattice model for DNA bricks results in robust self-assembly into a variety of target structures.

Graphical abstract: DNA brick self-assembly with an off-lattice potential

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Publication details

The article was received on 03 May 2016, accepted on 06 Jun 2016 and first published on 07 Jun 2016


Article type: Paper
DOI: 10.1039/C6SM01031H
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Citation: Soft Matter, 2016,12, 6253-6260
  • Open access: Creative Commons BY license
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    DNA brick self-assembly with an off-lattice potential

    A. Reinhardt and D. Frenkel, Soft Matter, 2016, 12, 6253
    DOI: 10.1039/C6SM01031H

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