Jump to main content
Jump to site search

Issue 4, 2016
Previous Article Next Article

Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties

Author affiliations

Abstract

The design of self-standing multilayered structures based on biopolymers has been attracting increasing interest due to their potential in the biomedical field. However, their use has been limited due to their gel-like properties. Herein, we report the combination of covalent and ionic cross-linking, using natural and non-cytotoxic cross-linkers, such as genipin and calcium chloride (CaCl2). Combining both cross-linking types the mechanical properties of the multilayers increased and the water uptake ability decreased. The ionic cross-linking of multilayered chitosan (CHI)–alginate (ALG) films led to freestanding membranes with multiple interesting properties, such as: improved mechanical strength, calcium-induced adhesion and shape memory ability. The use of CaCl2 also offered the possibility of reversibly switching all of these properties by simple immersion in a chelate solution. We attribute the switch-ability of the mechanical properties, shape memory ability and the propensity for induced-adhesion to the ionic cross-linking of the multilayers. These findings suggested the potential of the developed polysaccharide freestanding membranes in a plethora of research fields, including in biomedical and biotechnological fields.

Graphical abstract: Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Oct 2015, accepted on 19 Nov 2015 and first published on 20 Nov 2015


Article type: Paper
DOI: 10.1039/C5SM02458G
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2016,12, 1200-1209
  •   Request permissions

    Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties

    J. M. Silva, S. G. Caridade, R. L. Reis and J. F. Mano, Soft Matter, 2016, 12, 1200
    DOI: 10.1039/C5SM02458G

Search articles by author

Spotlight

Advertisements