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Issue 4, 2016
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Enzymatically triggered rupture of polymersomes

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Abstract

Polymersomes are robust vesicles made from amphiphilic block co-polymers. Large populations of uniform giant polymersomes with defined, entrapped species can be made by templating of double-emulsions using microfluidics. In the present study, a series of two enzymatic reactions, one inside and the other outside of the polymersome, were designed to induce rupture of polymersomes. We measured how the kinetics of rupture were affected by altering enzyme concentration. These results suggest that protocells with entrapped enzymes can be engineered to secrete contents on cue.

Graphical abstract: Enzymatically triggered rupture of polymersomes

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Publication details

The article was received on 28 Jul 2015, accepted on 11 Nov 2015 and first published on 11 Nov 2015


Article type: Communication
DOI: 10.1039/C5SM01881A
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2016,12, 1014-1020
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    Enzymatically triggered rupture of polymersomes

    W. Jang, S. C. Park, E. H. Reed, K. P. Dooley, S. F. Wheeler, D. Lee and D. A. Hammer, Soft Matter, 2016, 12, 1014
    DOI: 10.1039/C5SM01881A

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