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Issue 8, 2016
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Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

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Abstract

A series of fluorescent anion transporters consisting of a urea or thiourea group linked to a naphthalimide fluorophore have been synthesised and their anion transport properties studied. The compounds possess similar anion transport properties to (thio)urea-based anionophores that have previously been reported. Fluorescence studies in cells show all anionophores cross the plasma membrane and localise within the interior of cells. The most lipophilic, aromatic substituted transporters localise homogeneously throughout the cell and are toxic towards cancer cells with the highly fluorinated compound 6 being the most effective. The least lipophilic, alkyl substituted transporters localise in specific vesicles and are non-toxic to cells. This work provides new insight to the actions of anionophores in cells and may be useful in the design of novel antineoplastic agents.

Graphical abstract: Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

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Publication details

The article was received on 17 Sep 2015, accepted on 15 Apr 2016 and first published on 26 Apr 2016


Article type: Edge Article
DOI: 10.1039/C6SC01643J
Citation: Chem. Sci., 2016,7, 5069-5077
  • Open access: Creative Commons BY license
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    Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

    S. N. Berry, V. Soto-Cerrato, E. N. W. Howe, H. J. Clarke, I. Mistry, A. Tavassoli, Y. Chang, R. Pérez-Tomás and P. A. Gale, Chem. Sci., 2016, 7, 5069
    DOI: 10.1039/C6SC01643J

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