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Issue 4, 2016
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The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

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Abstract

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C–H arylations, a copper-catalysed C–H amination and a palladium-catalysed C–H carbonylation, which build up the structural complexity of the natural product framework.

Graphical abstract: The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

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Publication details

The article was received on 17 Nov 2015, accepted on 12 Jan 2016 and first published on 21 Jan 2016


Article type: Edge Article
DOI: 10.1039/C5SC04399A
Citation: Chem. Sci., 2016,7, 2706-2710
  • Open access: Creative Commons BY license
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    The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy

    J. C. Fox, R. E. Gilligan, A. K. Pitts, H. R. Bennett and M. J. Gaunt, Chem. Sci., 2016, 7, 2706
    DOI: 10.1039/C5SC04399A

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