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Issue 5, 2016
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Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

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Abstract

A series of porphyrin–fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.

Graphical abstract: Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

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Publication details

The article was received on 31 Oct 2015, accepted on 02 Feb 2016 and first published on 17 Feb 2016


Article type: Edge Article
DOI: 10.1039/C5SC04135J
Citation: Chem. Sci., 2016,7, 3331-3337
  • Open access: Creative Commons BY-NC license
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    Optical control of neuronal firing via photoinduced electron transfer in donor–acceptor conjugates

    Y. Takano, T. Numata, K. Fujishima, K. Miyake, K. Nakao, W. D. Grove, R. Inoue, M. Kengaku, S. Sakaki, Y. Mori, T. Murakami and H. Imahori, Chem. Sci., 2016, 7, 3331
    DOI: 10.1039/C5SC04135J

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      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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      [Original citation] - Published by The Royal Society of Chemistry.

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