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Issue 3, 2016
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Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles

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Abstract

We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.

Graphical abstract: Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles

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Publication details

The article was received on 30 Sep 2015, accepted on 08 Dec 2015 and first published on 23 Dec 2015


Article type: Edge Article
DOI: 10.1039/C5SC03717D
Citation: Chem. Sci., 2016,7, 2392-2398
  • Open access: Creative Commons BY license
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    Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles

    C. Carling, J. Olejniczak, A. Foucault-Collet, G. Collet, M. L. Viger, V. A. Nguyen Huu, B. M. Duggan and A. Almutairi, Chem. Sci., 2016, 7, 2392
    DOI: 10.1039/C5SC03717D

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