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Issue 1, 2016
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An enantioselective artificial Suzukiase based on the biotin–streptavidin technology

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Abstract

Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee. The hybrid catalyst described herein shows comparable TOF to the previous aqueous-asymmetric Suzuki catalysts, and excellent stability under the reaction conditions to realize higher TON through longer reaction time.

Graphical abstract: An enantioselective artificial Suzukiase based on the biotin–streptavidin technology

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Publication details

The article was received on 21 Aug 2015, accepted on 17 Oct 2015, published on 19 Oct 2015 and first published online on 19 Oct 2015


Article type: Edge Article
DOI: 10.1039/C5SC03116H
Citation: Chem. Sci., 2016,7, 673-677
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    An enantioselective artificial Suzukiase based on the biotin–streptavidin technology

    A. Chatterjee, H. Mallin, J. Klehr, J. Vallapurackal, A. D. Finke, L. Vera, M. Marsh and T. R. Ward, Chem. Sci., 2016, 7, 673
    DOI: 10.1039/C5SC03116H

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