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Issue 5, 2016
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A miniature CSTR cascade for continuous flow of reactions containing solids

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Abstract

Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels–Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N′-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging.

Graphical abstract: A miniature CSTR cascade for continuous flow of reactions containing solids

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Publication details

The article was received on 15 Jul 2016, accepted on 29 Jul 2016 and first published on 16 Aug 2016


Article type: Paper
DOI: 10.1039/C6RE00132G
Citation: React. Chem. Eng., 2016,1, 501-507
  • Open access: Creative Commons BY license
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    A miniature CSTR cascade for continuous flow of reactions containing solids

    Y. Mo and K. F. Jensen, React. Chem. Eng., 2016, 1, 501
    DOI: 10.1039/C6RE00132G

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