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Issue 2, 2016
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Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

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Abstract

A new enabling technology for performing photochemical reactions in a continuous fashion is presented. This photo-reactor is compatible with existing flow systems and can be furthermore linked to a photo-spectrometer in order to allow for real time analysis of photochemical reactions. In this communication we wish to report the profiling of this system and its application to the continuous synthesis of ibuprofen based on a photo-Favorskii rearrangement reaction of a readily available α-chloropropiophenone precursor.

Graphical abstract: Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

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Publication details

The article was received on 21 Sep 2015, accepted on 19 Oct 2015, published on 04 Nov 2015 and first published online on 04 Nov 2015


Article type: Communication
DOI: 10.1039/C5RE00037H
Citation: React. Chem. Eng., 2016,1, 147-150
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    Continuous photochemistry: the flow synthesis of ibuprofen via a photo-Favorskii rearrangement

    M. Baumann and I. R. Baxendale, React. Chem. Eng., 2016, 1, 147
    DOI: 10.1039/C5RE00037H

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