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Issue 85, 2016, Issue in Progress
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Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative

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Abstract

The long-standing discussion of the absolute configuration of erythro-mefloquine is revisited, showcasing the strength of a combination of experimental and calculated vibrational circular dichroism spectroscopy. The resulting assignment of one of the most important antimalarials is subsequently confirmed by electronic circular dichroism spectroscopy and X-ray diffraction-based structure elucidation of thiourea derivatives, adding to the amount of evidence on the absolute configuration that had long remained a matter of debate.

Graphical abstract: Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative

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Publication details

The article was received on 31 Jul 2016, accepted on 19 Aug 2016 and first published on 22 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA19367F
Citation: RSC Adv., 2016,6, 81461-81465
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    Absolute configuration of the antimalarial erythro-mefloquine – vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative

    M. Kohout, J. Vandenbussche, A. Roller, J. Tůma, J. Bogaerts, P. Bultinck, W. Herrebout and W. Lindner, RSC Adv., 2016, 6, 81461
    DOI: 10.1039/C6RA19367F

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