Heparin-immobilized gold-assisted controlled release of growth factors via electrochemical modulation

Abstract

We developed a versatile platform for the electrochemical release of growth factors assisted by a heparin-immobilized gold surface. The controlled release of basic fibroblast growth factor (bFGF) from heparinized gold could be effectively modulated by biphasic electrochemical stimulation which actively controlled specific interactions between heparin and bFGF in a remote manner so that the released bFGF maintained its bioactivity.