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Issue 95, 2016
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The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

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Abstract

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1 : 1 pentane–isopentane mixture.

Graphical abstract: The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

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Publication details

The article was received on 12 Jul 2016, accepted on 21 Sep 2016 and first published on 21 Sep 2016


Article type: Paper
DOI: 10.1039/C6RA17750F
Citation: RSC Adv., 2016,6, 92629-92637
  • Open access: Creative Commons BY-NC license
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    The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

    B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov and E. V. Boldyreva, RSC Adv., 2016, 6, 92629
    DOI: 10.1039/C6RA17750F

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