Influence of molecular weight on kinetics release of metronidazole from proline-based polymers prepared by RAFT polymerization

Mohamed H. El-Newehy; Abeer S. Elsherbiny; Hideharu Mori

doi:10.1039/C6RA14307E

Influence of molecular weight on kinetics release of metronidazole from proline-based polymers prepared by RAFT polymerization

Mohamed H. El-Newehy,*^a^b^c Abeer S. Elsherbiny^a^d and Hideharu Mori^b

Author affiliations

* Corresponding authors

^a Chemistry Department, Faculty of Science, Tanta University, Tanta 31527, Egypt
E-mail: melnewehy@hotmail.com, melnewehy@ksu.edu.sa

^b Department of Polymer Science and Engineering, Graduate, School of Science and Engineering, Yamagata University, 4-3-16, Jonan, Yonezawa 992-8510, Japan

^c Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

^d Chemistry Department, College of Science and Art, King Abdulaziz University, Rabigh Campus, Rabigh 21911, Saudi Arabia

Abstract

In the current study, the influence of polymer molecular weight on the release of metronidazole (MTZ) as a drug model from synthesized proline-based polymers was studied. Using reversible-addition fragmentation chain transfer (RAFT) polymerization, amino acid-based polymers based on N-acryloyl-L-proline (A-L-Pro-OH) with various molecular weights were prepared with relatively high conversions (55–98%, as measured by ¹H NMR spectroscopy). The polymerization process was done at different ratios of [monomer]₀/[CTA]₀/[AIBN]₀. Proline-based polymers with pre-determined molecular weights (M_n = 6000–22 600 in methylated forms) and low polydispersities (M_w/M_n = 1.30–1.37) were utilized for the immobilization of metronidazole. The kinetics release studies of the polymer-MTZ adducts were done at various pH values: 2.0, 7.4, and 8.5 phosphate buffer solutions. The obtained results proved that the hydrolytic behaviors of polymeric prodrugs robustly relied on the molecular weight of the polymer and the pH of the release media. The kinetics of the release process were described using Higuchi and Korsmeyer's models to explain the drug release mechanism.

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Publication details

The article was received on 02 Jun 2016, accepted on 22 Jul 2016 and first published on 22 Jul 2016

Article type: Paper

DOI: 10.1039/C6RA14307E

Citation: RSC Adv., 2016,6, 72761-72767

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Influence of molecular weight on kinetics release of metronidazole from proline-based polymers prepared by RAFT polymerization

M. H. El-Newehy, A. S. Elsherbiny and H. Mori, RSC Adv., 2016, 6, 72761
DOI: 10.1039/C6RA14307E
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Influence of molecular weight on kinetics release of metronidazole from proline-based polymers prepared by RAFT polymerization

Abstract

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Influence of molecular weight on kinetics release of metronidazole from proline-based polymers prepared by RAFT polymerization

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