Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

Marin Simeonov; Bistra Kostova; Elena Vassileva

doi:10.1039/C6RA14067J

Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

Marin Simeonov,^a Bistra Kostova^b and Elena Vassileva*^a

Author affiliations

* Corresponding authors

^a Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier blvd., 1164 Sofia, Bulgaria
E-mail: evassileva@chem.uni-sofia.bg

^b Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2, Dunav Str., Sofia, Bulgaria

Abstract

Novel interpenetrating polymer networks (IPN) of poly(methacrylic acid) (PMAA) and polyacrylamide (PAAm) were synthesized and characterized in terms of their swelling ability, microhardness and morphology. The potential of these new polymeric materials as a sustained delivery system for cationic drug was revealed. The study demonstrates that the IPN's composition is a powerful tool to control the IPN's structure and properties and hence their performance as a new polymeric system for sustained drug delivery.

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Publication details

The article was received on 30 May 2016, accepted on 29 Jun 2016 and first published on 30 Jun 2016

Article type: Paper

DOI: 10.1039/C6RA14067J

Citation: RSC Adv., 2016,6, 64239-64246

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Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

M. Simeonov, B. Kostova and E. Vassileva, RSC Adv., 2016, 6, 64239
DOI: 10.1039/C6RA14067J
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Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

Abstract

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Interpenetrating polymer networks of poly(methacrylic acid) and polyacrylamide: synthesis, characterization and potential application for sustained drug delivery

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