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Issue 59, 2016, Issue in Progress
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Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

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Abstract

Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.

Graphical abstract: Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

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Publication details

The article was received on 17 May 2016, accepted on 30 May 2016 and first published on 01 Jun 2016


Article type: Paper
DOI: 10.1039/C6RA12856D
Citation: RSC Adv., 2016,6, 54331-54335
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    Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

    R. Raliya, A. Som, N. Shetty, N. Reed, S. Achilefu and P. Biswas, RSC Adv., 2016, 6, 54331
    DOI: 10.1039/C6RA12856D

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