Thermodynamic stability of hydroxymethylcytosine (hmC) containing CpG repeats showed that though hmC destabilizes hypomethylated CpG, this effect can be reversed in a heavily methylated duplex. This dual-epigenetic modulation on duplex stability was also observed in cellular-mimic crowding conditions for both A-form DNA–RNA hybrids and B-form DNA–DNA duplexes.
Q. Wu, J. R. Wong, P. L. Qing Yeo, D. Zhang and F. Shao, RSC Adv., 2016, 6, 48858 DOI: 10.1039/C6RA08647K
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
