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Issue 55, 2016, Issue in Progress
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Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion

Y. Vida,ab  D. Collado,ab  F. Najera,ab  S. Claros,c  J. Becerra,bc  J. A. Andrades*c  and  E. Perez-Inestrosa*ab 
Author affiliations

* Corresponding authors

a Universidad de Malaga, IBIMA, Department of Organic Chemistry, 29071-Malaga, Spain
E-mail: inestrosa@uma.es

b Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Parque Tecnologico de Andalucia, 29590-Malaga, Spain

c Universidad de Malaga, Cell Biology, Genetics and Physiology Department, Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine-CIBER-BBN, 29071-Malaga, Spain

Abstract

Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface material are critical. Arginine-glycine-aspartic acid tripeptides (RGD) were conjugated to polyamidoamine (PAMAM) dendrimers and used to pre-treat test surfaces. We demonstrate that pre-treatment with dendrimer-presented tripeptides efficiently increases MSC adhesion to a polystyrene test surface, and that treatment effectiveness is related to how tripeptides are presented by the dendrimer to the cell. We tested both R-G-D–dendrimer and dendrimer–R-G-D arrangements and found the former to be optimal in terms of surface adhesion.

Graphical abstract: Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion

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Publication details

The article was received on 08 Mar 2016, accepted on 14 May 2016 and first published on 17 May 2016


Article type: Paper
DOI: 10.1039/C6RA06177J
Citation: RSC Adv., 2016,6, 49839-49844
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    Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion

    Y. Vida, D. Collado, F. Najera, S. Claros, J. Becerra, J. A. Andrades and E. Perez-Inestrosa, RSC Adv., 2016, 6, 49839
    DOI: 10.1039/C6RA06177J

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