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Issue 46, 2016, Issue in Progress
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Solid phase syntheses of S,N-substituted 2-mercaptobenzoimidazoles

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Abstract

2-Mercaptobenzoimidazoles are an important class of heterocycles showing biological activity in diverse therapeutic applications. In the presented study, a strategy for the syntheses of substituted 2-mercaptobenzoimidazoles on solid supports is shown. After immobilization of the benzoimidazole core on a functionalized resin and its modification via the Mitsunobu reaction, the target 2-mercaptobenzoimidazoles are cleaved either via transesterification or aminolysis giving functionalized S,N-dialkylated mercaptobenzoimidazoles.

Graphical abstract: Solid phase syntheses of S,N-substituted 2-mercaptobenzoimidazoles

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Publication details

The article was received on 03 Mar 2016, accepted on 02 Apr 2016 and first published on 20 Apr 2016


Article type: Communication
DOI: 10.1039/C6RA05702K
Citation: RSC Adv., 2016,6, 39573-39576
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    Solid phase syntheses of S,N-substituted 2-mercaptobenzoimidazoles

    S. Susanto, N. Jung and S. Bräse, RSC Adv., 2016, 6, 39573
    DOI: 10.1039/C6RA05702K

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