Jump to main content
Jump to site search

Issue 58, 2016, Issue in Progress
Previous Article Next Article

Study of mesoporous magnesium carbonate in contact with whole human blood

Author affiliations

Abstract

The interaction of mesoporours magnesium carbonate (Upsalite) particles (50–100 μm) with human whole blood was investigated using an in vitro loop model and the effect on the complement system, blood coagulation and red blood cell lysis was assessed. The removal of Ca2+ by Upsalite and the possible exchange with and/or release of Mg2+ were explored as well. Upsalite was found to present anticoagulant properties, most probably due to the uptake of Ca2+ by the particles. No hemolytic activity was detected at Upsalite concentrations up to 1 mg ml−1. Moderate to high levels of C3a and sC5b-9 were observed for Upsalite, however such levels were statistically different from the negative control only when the particle concentrations were 0.25 mg ml−1 and 1.0 mg ml−1, respectively. The presented findings are promising for the future development of mesoporous magnesium carbonate-based materials for biomedical applications.

Graphical abstract: Study of mesoporous magnesium carbonate in contact with whole human blood

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Mar 2016, accepted on 23 May 2016 and first published on 25 May 2016


Article type: Paper
DOI: 10.1039/C6RA05679B
Citation: RSC Adv., 2016,6, 52810-52816
  •   Request permissions

    Study of mesoporous magnesium carbonate in contact with whole human blood

    S. Frykstrand, J. Forsgren, O. Cheung, P. Zhang, J. Hong, M. Strømme and N. Ferraz, RSC Adv., 2016, 6, 52810
    DOI: 10.1039/C6RA05679B

Search articles by author

Spotlight

Advertisements