Issue 36, 2016
From the journal:

RSC Advances

Novel micellar form of poplar propolis with high cytotoxic activity†

Petar D. Petrov,*a   Christo B. Tsvetanov,a   Pavlina Mokreva,a   Krassimira Yoncheva,b   Spiro Konstantinov,c   Boryana Trusheva,d   Milena Popovad  and  Vassya Bankovad  

* Corresponding authors

a Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
E-mail: ppetrov@polymer.bas.bg
Fax: +359 28700309
Tel: +359 29792281

b Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria

c Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria

d Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Abstract

A novel micellar form of propolis based on a biocompatible poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) block copolymer (PEO26PPO40PEO26) is developed. Beneficially, all biologically active lipophilic constituents of propolis are solubilized with the aid of polymeric micelles in aqueous media. The micellar form of the propolis exhibits high in vitro cytotoxicity at relatively low concentrations.

Graphical abstract: Novel micellar form of poplar propolis with high cytotoxic activity

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Article information

DOI
https://doi.org/10.1039/C6RA03577A
Article type
Communication
Submitted
08 Feb 2016
Accepted
17 Mar 2016
First published
21 Mar 2016

RSC Adv., 2016,6, 30728-30731

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Novel micellar form of poplar propolis with high cytotoxic activity

P. D. Petrov, C. B. Tsvetanov, P. Mokreva, K. Yoncheva, S. Konstantinov, B. Trusheva, M. Popova and V. Bankova, RSC Adv., 2016, 6, 30728 DOI: 10.1039/C6RA03577A

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