Preparation of ORMOSIL nanoparticles conjugated with vitamin D3 analogues and their biological evaluation

Tania González-García; Susana Fernández; Elisa Lubian; Fabrizio Mancin; Miguel Ferrero

doi:10.1039/C6RA02965E

Preparation of ORMOSIL nanoparticles conjugated with vitamin D₃ analogues and their biological evaluation

Tania González-García,^a^b Susana Fernández,^a Elisa Lubian,^b Fabrizio Mancin*^b and Miguel Ferrero*^a

Author affiliations

* Corresponding authors

^a Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006-Oviedo, Spain
E-mail: mferrero@uniovi.es
Tel: +34 985 105 013

^b Dipartimento di Scienze Chimiche, Universitá di Padova, 35131-Padova, Italy
E-mail: fabrizio.mancin@unipd.it
Tel: +39 0498 275 666

Abstract

Dye-doped, 90 nm diameter, multifunctional organically modified silica (ORMOSIL) nanoparticles were prepared by condensation of vinyltriethoxysilane within surfactant-stabilized microemulsions and conjugated with several vitamin D₃ derivatives. For this, vitamin D analogues possessing at least one hydroxyl group derivatized as vinylcarbonate have been synthesized. These analogues were conjugated to ORMOSIL nanoparticles through the carbonate function, forming carbamate derivatives of vitamin D nanoparticles. The interaction between these nanoparticles and human serum albumin, which is one of the serum transporters of the insoluble vitamin D₃, was investigated by surface plasmon resonance. The results obtained revealed that this approach allows obtaining water-soluble vitamin D₃ derivatives, which maintain their full protein binding ability.

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Publication details

The article was received on 01 Feb 2016, accepted on 21 Mar 2016 and first published on 24 Mar 2016

Article type: Paper

DOI: 10.1039/C6RA02965E

Citation: RSC Adv., 2016,6, 31840-31849

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Preparation of ORMOSIL nanoparticles conjugated with vitamin D₃ analogues and their biological evaluation

T. González-García, S. Fernández, E. Lubian, F. Mancin and M. Ferrero, RSC Adv., 2016, 6, 31840
DOI: 10.1039/C6RA02965E
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Preparation of ORMOSIL nanoparticles conjugated with vitamin D₃ analogues and their biological evaluation

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Preparation of ORMOSIL nanoparticles conjugated with vitamin D₃ analogues and their biological evaluation

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