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Issue 40, 2016, Issue in Progress
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Multi-modal imaging of HeLa cells using a luminescent ZnS:Mn/NaGdF4:Yb:Er nanocomposite with enhanced upconversion red emission

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Abstract

The multi-modal luminescence properties of the ZnS:Mn/NaGdF4:Yb:Er nanocomposite were investigated. The ZnS:Mn/NaGdF4:Yb:Er nanocomposite was synthesized using a single-step hot injection method. Its crystallinity was confirmed using X-ray diffraction, and was compared with the crystallinities of NaGdF4:Yb:Er nanoparticles and ZnS:Mn quantum dots synthesized by thermal decomposition. Composite formation and morphology changes were investigated by transmission electron microscopy. Enhanced upconversion red emission (654 nm, 4F9/24I15/2) was observed for NaGdF4:Yb:Er in the presence of ZnS:Mn. Analysis of the excitation and downconversion emission spectra of ZnS:Mn/NaGdF4:Yb:Er indicated modified emission at lower wavelengths. Cathodoluminescence measurements indicated that the ZnS:Mn/NaGdF4:Yb:Er nanocomposite had a broad visible emission from green to red wavelengths. Cytotoxicity and stability measurements were executed to ensure the toxicity of the synthesized composite and their luminescence stability in water as well as phosphate buffered solution. The nanocomposite had multi-modal characteristics, and was used in the upconversion and downconversion optical imaging of living He–La cells. The multi-modal luminescence capability of the nanocomposite was suitable for upconversion and downconversion imaging.

Graphical abstract: Multi-modal imaging of HeLa cells using a luminescent ZnS:Mn/NaGdF4:Yb:Er nanocomposite with enhanced upconversion red emission

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Publication details

The article was received on 27 Jan 2016, accepted on 29 Mar 2016 and first published on 30 Mar 2016


Article type: Paper
DOI: 10.1039/C6RA02422J
Citation: RSC Adv., 2016,6, 33569-33579
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    Multi-modal imaging of HeLa cells using a luminescent ZnS:Mn/NaGdF4:Yb:Er nanocomposite with enhanced upconversion red emission

    D. Thangaraju, Y. Masuda, I. K. Mohamed Mathar Sahip, W. Inami, Y. Kawata and Y. Hayakawa, RSC Adv., 2016, 6, 33569
    DOI: 10.1039/C6RA02422J

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