Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi

Ming-Ming Cao; Yu Zhang; Zong-Gen Peng; Jian-Dong Jiang; Yue-Jiao Gao; Xiao-Jiang Hao

doi:10.1039/C5RA25218K

Schoberine B, an alkaloid with an unprecedented straight C₅ side chain, and myriberine B from Myrioneuron faberi

Ming-Ming Cao,^a^b Yu Zhang,^a Zong-Gen Peng,^c Jian-Dong Jiang,^c Yue-Jiao Gao^b and Xiao-Jiang Hao*^a

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* Corresponding authors

^a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China
E-mail: haoxj@mail.kib.ac.cn
Fax: +86-871-65223070
Tel: +86-871-65223263

^b College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China

^c Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China

Abstract

Two novel Myrioneuron alkaloids, schoberine B (1) and myriberine B (2), were isolated from the aerial part of Myrioneuron faberi. Schoberine B is the first example among lysine-originating alkaloids to possess a ring-free C₅ fragment as a side chain. The structures of 1 and 2 were elucidated using analyses of extensive NMR and MS spectra. 1 and 2 were evaluated in vitro against hepatitis C virus (HCV), showing a therapeutic index (CC₅₀/EC₅₀) of higher than 36.2 and 15.2, respectively.

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The article was received on 27 Nov 2015, accepted on 14 Jan 2016 and first published on 18 Jan 2016

Article type: Communication

DOI: 10.1039/C5RA25218K

Citation: RSC Adv., 2016,6, 10180-10184

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Schoberine B, an alkaloid with an unprecedented straight C₅ side chain, and myriberine B from Myrioneuron faberi

M. Cao, Y. Zhang, Z. Peng, J. Jiang, Y. Gao and X. Hao, RSC Adv., 2016, 6, 10180
DOI: 10.1039/C5RA25218K
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Schoberine B, an alkaloid with an unprecedented straight C₅ side chain, and myriberine B from Myrioneuron faberi

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Schoberine B, an alkaloid with an unprecedented straight C₅ side chain, and myriberine B from Myrioneuron faberi

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