Jump to main content
Jump to site search

Issue 18, 2016
Previous Article Next Article

The effect of protein concentration on the viscosity of a recombinant albumin solution formulation

Author affiliations

Abstract

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied. The level of protein aggregation with concentration and its impact on solution viscosity was investigated. Theoretical models predicting viscosity with concentration were applied to these data, and a model that accounts for multiple protein species in solution provided the best fit. The results highlight the need to account for heterogeneity in the level of aggregation when addressing the increase of viscosity observed at high concentrations of protein solutions, a significant issue for the manufacture and use of protein-based therapeutics.

Graphical abstract: The effect of protein concentration on the viscosity of a recombinant albumin solution formulation

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Oct 2015, accepted on 28 Jan 2016 and first published on 29 Jan 2016


Article type: Paper
DOI: 10.1039/C5RA21068B
Citation: RSC Adv., 2016,6, 15143-15154
  •   Request permissions

    The effect of protein concentration on the viscosity of a recombinant albumin solution formulation

    A. D. Gonçalves, C. Alexander, C. J. Roberts, S. G. Spain, S. Uddin and S. Allen, RSC Adv., 2016, 6, 15143
    DOI: 10.1039/C5RA21068B

Search articles by author