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Issue 3, 2016
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A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

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Abstract

Fluorinated solvents like 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have recently emerged as a remarkable synthetic solution allowing challenging C–H activation reactions. A beneficial effect of these solvents on reactivity, as well as site- and stereoselectivity of various direct functionalization reactions has been observed. Moreover, several catalytic systems specifically require such fluorinated medium. This Highlight is devoted to showcasing the exceptional potential of fluorinated alcohols in the C–H activation field.

Graphical abstract: A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

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Publication details

The article was received on 24 Nov 2015, accepted on 18 Jan 2016 and first published on 02 Feb 2016


Article type: Highlight
DOI: 10.1039/C5QO00398A
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2016,3, 394-400
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    A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

    J. Wencel-Delord and F. Colobert, Org. Chem. Front., 2016, 3, 394
    DOI: 10.1039/C5QO00398A

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