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Issue 2, 2016
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Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

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Abstract

Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF3-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF3-containing lactams that are of great potential in pharmaceuticals and agrochemicals.

Graphical abstract: Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

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Publication details

The article was received on 05 Nov 2015, accepted on 05 Dec 2015 and first published on 10 Dec 2015


Article type: Research Article
DOI: 10.1039/C5QO00353A
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2016,3, 222-226
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    Copper-catalyzed aminotrifluoromethylation of alkenes: a facile synthesis of CF3-containing lactams

    K. Shen and Q. Wang, Org. Chem. Front., 2016, 3, 222
    DOI: 10.1039/C5QO00353A

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