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Issue 2, 2016
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Rhenium and base co-catalyzed [3 + 2] annulations of N–H ketimines and alkynes to access unprotected tertiary indenamines through C–H bond activation

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Abstract

Herein, a rhenium-catalyzed [3 + 2] carbocyclization of N–H ketimines and alkynes through C–H bond activation to afford unprotected tertiary indenamines is described. Notably, the catalytic use of a cheap base, sodium carbonate, was demonstrated to be crucial to the success of this reaction. The protocol is also highlighted by a high atom-economy, a broad substrate scope, and excellent regioselectivity for unsymmetrical alkynes.

Graphical abstract: Rhenium and base co-catalyzed [3 + 2] annulations of N–H ketimines and alkynes to access unprotected tertiary indenamines through C–H bond activation

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Publication details

The article was received on 30 Oct 2015, accepted on 17 Dec 2015 and first published on 24 Dec 2015


Article type: Research Article
DOI: 10.1039/C5QO00336A
Citation: Org. Chem. Front., 2016,3, 268-272
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    Rhenium and base co-catalyzed [3 + 2] annulations of N–H ketimines and alkynes to access unprotected tertiary indenamines through C–H bond activation

    X. Jin, X. Yang, Y. Yang and C. Wang, Org. Chem. Front., 2016, 3, 268
    DOI: 10.1039/C5QO00336A

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