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Issue 27, 2016
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Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

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Abstract

Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1–3 as well as five novel GBLs named SCB4–8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1–3 and established those of SCB4–8.

Graphical abstract: Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

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Publication details

The article was received on 19 Apr 2016, accepted on 10 May 2016 and first published on 10 May 2016


Article type: Communication
DOI: 10.1039/C6OB00840B
Citation: Org. Biomol. Chem., 2016,14, 6390-6393
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    Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152

    J. D. Sidda, V. Poon, L. Song, W. Wang, K. Yang and C. Corre, Org. Biomol. Chem., 2016, 14, 6390
    DOI: 10.1039/C6OB00840B

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